What is a syntax trial?

SYNTAX is a novel, randomized trial with nested registries comparing PCI with paclitaxel-eluting TAXUS stents to CABG for 3VD and LM patients to evaluate the best treatment for these patients with complex coronary disease.

What is a syntax score in cardiology?

The SYNTAX score is a grading system that evaluates the complexity and prognosis of patients undergoing percutaneous coronary intervention (PCI). We investigated the association between the incidence of major adverse cardiac events (MACE) following PCI and the SYNTAX score in patients with three-vessel disease.

What is the ischemia trial?

The purpose of the ISCHEMIA trial is to determine the best management strategy for higher-risk patients with stable ischemic heart disease (SIHD). This is a multicenter randomized controlled trial with 5179 randomized participants with moderate or severe ischemia on stress testing.

What is a graft in the heart?

The procedure A coronary artery bypass graft involves taking a blood vessel from another part of the body (usually the chest, leg or arm) and attaching it to the coronary artery above and below the narrowed area or blockage. This new blood vessel is known as a graft.

What is the Courage trial?

The Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial was designed to determine whether percutaneous coronary intervention (PCI) coupled with optimal medical therapy (OMT) reduced the risk of death or nonfatal myocardial infarction in patients with stable coronary artery …

What is a normal syntax score?

Baseline SYNTAX Score It is a visual estimate of CAD burden and complexity. The SYNTAX score takes into account complex lesions including bifurcations, chronic total occlusions, thrombus, calcification, and small diffuse disease. The score ranges from 0 to greater than 60 in very complex coronary anatomy lesions.

How do you use Syntax score?

The SYNTAX score algorithm takes into account the location of a lesion (coronary tree segments are weighted depending on their location), if a lesion is occlusive or nonocclusive (multiplication factor of 5 or 2, respectively), and all other adverse lesion characteristics (assigned additive values).

Is a CABG a PCI?

Percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) are considered revascularization procedures, but only CABG can prolong life in stable coronary artery disease. Thus, PCI and CABG mechanisms may differ.

Which is better stent or bypass surgery?

“For three-vessel coronary disease, bypass now has been shown to be superior to stenting, with the possible exception of some cases in which the narrowing in the artery is very short,” Cutlip says. “But by and large the debate is settled that bypass surgery is better.”

What is the treatment for ischemia?

Treatment for myocardial ischemia involves improving blood flow to the heart muscle. Treatment may include medications, a procedure to open blocked arteries (angioplasty) or bypass surgery.

Is the ischemia trial published?

The ISCHEMIA main results publication was selected by NEJM editors as one of the most notable studies published in 2020. It was one of 14 studies designated by the editors as being the most meaningful in changing medical practice and impacting patient care in 2020.