Can you have a pheochromocytoma with normal metanephrines?
Results: Pheochromocytomas were associated with increases in plasma concentrations of metanephrines that were greater and more consistent than those in plasma catecholamine concentrations. No patient with a pheochromocytoma had normal plasma concentrations of both normetanephrine and metanephrine.
Can a blood test detect pheochromocytoma?
Blood tests are available for metanephrine, normetanephrine, and chromogranin A. The most commonly ordered blood test for pheochromocytoma is the plasma free metanephrine test.
What do high VMA levels mean?
Vanillylmandelic acid (VMA) and other catecholamine metabolites (homovanillic acid: HVA and dopamine) are typically elevated in patients with catecholamine-secreting tumors (eg, neuroblastoma, pheochromocytoma, and other neural crest tumors).
What can cause elevated metanephrines?
Higher levels of metanephrines may mean that you have an adrenal gland tumor. But false-positive results can happen. Higher levels may also be caused by obstructive sleep apnea, stress, or other illnesses.
How long do Metanephrines stay in your system?
For the 24-hour urine collection, all urine should be saved for a 24-hour period. Empty the bladder completely without collecting. Then collect urine for 24 hours only – no more than 24 hours. It is important that the sample be refrigerated during this time.
What is the normal level of Metanephrines urine?
Metanephrine: 24 to 96 mcg/24 hours (some laboratories give the range as 140 to 785 mcg/24 hours) Norepinephrine: 15 to 80 mcg/24 hours (89 to 473 nmol/24 hours)
What is normal VMA level?
VMA: 2 to 7 milligrams (mg)/24 hours (10 to 35 mcmol/24 hours)
What is a VMA blood test used for?
The vanillylmandelic acid (VMA) test is primarily used to detect and rule out tumors called neuroblastomas in children with an abdominal mass or other symptoms suggestive of the disease.
How long do metanephrines stay in your system?