By How do you synthesis benzocaine?
Local Anesthetics 1). The classic, optimal way of benzocaine synthesis is the reduction of the nitro group of the ethyl ester of 4-nitrobenzoic acid to benzocaine by hydrogen, which generates directly in the reaction medium by the reaction of iron filings with dilute acids [24–26].
How does Le Chatelier’s principle influence the benzocaine synthesis?
Le Chatelier’s Principle can be exploited to push the reaction toward the product side. In this synthesis of benzocaine, by using microwave heating, we will be able to successfully complete the actual reaction of benzocaine in just a couple of minutes.
How do you calculate theoretical yield of benzocaine?
Calculations: Theoretical yield= 0.126g 4-aminobenzoic acid x 165.192g benzocaine / 137.138g 4- aminobenzoic acid =0.152 g benzocaine Percent yield= 0.035 g product / 0.152 g theoretical x 100 = 23% Recorded melting point range: 92 to 94 °C ℃ Conclusion: The purpose of this experiment was to synthesize benzene in order …
How do you purify benzocaine?
Purifying the Benzocaine. a) Add a few mL of hot ethanol and heat the mixture on the steam bath until all the oil dissolves. b) Add water (drop wise!) to the alcohol solution until cloudiness just appears and then add a few drops of ethanol. Cool the mixture, with occasional VIGOROUS swirling, in an ice bath.
Why does benzocaine precipitate during neutralization?
Explain why benzocaine precipitates during the neutralization. With the addition of an acid, the amine group on the benzocaine will become protonated. The protonation creates a positive charge on the benzocaine molecule. Thus, the benzocaine will no longer be soluble and will precipitate during neutralization.
What is benzocaine most commonly used for?
Benzocaine topical is used to reduce pain or discomfort caused by minor skin irritations, sore throat, sunburn, vaginal or rectal irritation, ingrown toenails, hemorrhoids, and many other sources of minor pain on a surface of the body.
What is meant by Le Chatelier’s principle?
: a statement in physics and chemistry: if the equilibrium of a system is disturbed by a change in one or more of the determining factors (as temperature, pressure, or concentration) the system tends to adjust itself to a new equilibrium by counteracting as far as possible the effect of the change.
Is benzocaine acidic or basic?
Benzocaine is a benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component.
What is the molecular weight of benzocaine?
165.19 g/mol
Benzocaine/Molar mass
What can benzocaine be used for?
It works by blocking nerve signals in your body. Benzocaine topical is used to reduce pain or discomfort caused by minor skin irritations, sore throat, sunburn, vaginal or rectal irritation, ingrown toenails, hemorrhoids, and many other sources of minor pain on a surface of the body.
Where is benzocaine from?
Benzocaine is a chemical compound derived from para-aminobenzoic acid and ethanol. It is a white, odorless, crystalline powder. It acts on neuronal membranes and blocks nerve signals in the body. Its numbing effects are temporary.
What is the gas that is evolved during the neutralization?
So, we can say that sodium bicarbonate is a weak base. reacts with acetic acid, a neutralization reaction takes place and an aqueous salt of sodium acetate is formed along with the evolution of carbon dioxide gas. The gas evolved in the reaction is carbon dioxide, which is a colourless and odourless gas.