By What condition does alloxan cause?
Alloxan is a compound that can indeed destroy cells in the pancreas and cause diabetes in rats. Researchers use it to induce the disease so they can study treatments. But this compound, which is synthesized in the lab for medical research, has no other commercial application.
What is alloxan-induced diabetes?
Alloxan-induced diabetes is a form of insulin-dependent diabetes mellitus that occurs as a result of alloxan administration or injection to animals [78], [79]. It has been successfully induced in a variety of animal species; rabbits, mice, rats, monkeys, cats and dogs [80], [81].
What are the side effects of alloxan?
After injection of alloxan at the dose of 40 mg/kg, only a slight transient hyperglycemia was seen during the first 15 d. At 2 mo after alloxan injection, however, glucose- and carbachol-stimulated insulin secretion were markedly impaired in all animals treated with alloxan, including those with normoglycemia.
What is the difference between alloxan and streptozotocin?
Alloxan not only has toxic effects on islets of Langerhans, but also affect other body organs. It usually produces severe diabetes. Streptozotocin is more specific to beta cells rather than alloxan. strptozotocin has high inductive capacity than alloxan and its less toxic to the pancreas compared to alloxan .
Does alloxan cause diabetes in humans?
The beta cell toxic action of alloxan is initiated by free radicals formed in this redox reaction. Studies suggests that alloxan does not cause diabetes in humans.
What is the easiest thing you can do to help someone who has inadvertently taken an overdose of insulin?
Drink one-half cup of regular soda or sweetened fruit juice, and eat a hard candy or have glucose paste, tablets, or gel. If you skipped a meal, eat something now. Something with 15 to 20 grams of carbohydrates should raise your blood sugar. Rest.
Can alloxan induced type 2 diabetes in rats?
Alloxan and STZ induce T1DM in adults rats. But you can use STZ in newborn rats to induce T2DM. Alloxan cannot be used to induce T2DM. Some available models include fructose-fed, high fat diet fed followed by a low dose of STZ and STZ/nicotinamide.
How does alloxan induce diabetes in rats?
Diabetes was induced in 80 male albino rats by injecting 120 mg/kg of Alloxan monohydrate intra-peritoneally dissolved in 0.9% w/v cold normal saline to overnight-fasted rats (12 h). The rats were afterward kept for the next 24 h on 10% glucose solution bottles, in their cages, to prevent hypoglycemia.
Does Maida cause diabetes?
The glycemic index of maida is very high. It is not suitable to patients suffering from diabetes and obesity.
What are the signs of insulin overdose?
Symptoms of an Insulin Overdose
- Anxiety.
- Confusion.
- Extreme hunger.
- Fatigue.
- Irritability.
- Sweating or clammy skin.
- Trembling hands.
What happens if you take insulin when you don’t need it?
If a person takes too much insulin or takes it when they do not need it, it can be fatal. Occasionally, a person will use insulin in an attempt to take their life. If a person shows signs of severe depression or suicidal thoughts, they or a loved one should seek medical help or contact the National Suicide Helpline.