By Which statin is least likely to cause myopathy?
Even though all statins look similar chemically, they have some minor differences that could impact how likely they are to cause muscle pain. Simvastatin is the most likely to cause muscle pain, and fluvastatin and pitavastatin are the least likely.
Which statin has highest risk of myopathy?
Certain statins are associated with a higher incidence of myopathy. Bruckert et al used pravastatin as a reference and demonstrated that atorvastatin and simvastatin were associated with higher incidences of myopathy, whereas fluvastatin XL was associated with a lower incidence.
Which is better rosuvastatin or atorvastatin?
At the end of the titration-to-goal period, rosuvastatin was significantly more effective than atorvastatin on the primary efficacy measure, reducing LDL-C by 52% compared with 46% in the atorvastatin group (p < 0.0001) (table
Does Rosuvastatin cause myopathy?
Rosuvastatin is linked with high incidence of muscle-related adverse effects in comparison to other statins [5]. Incidences of myopathy have been reported with higher doses of Rosuvastatin. Product labelling in Europe highlights this risk at high doses of statins (40 mg once a day) [6].
What does statin myopathy feel like?
Symptoms of statin-induced myopathy Common complaints, especially in the lower body, include: cramps. heaviness. stiffness.
Will statin myopathy go away?
Statin-associated myopathy or myalgia is a well-known side effect of lipid-lowering agents. Usually, after discontinuation of the drug, symptoms alleviate and patients may be re-challenged with another statin. However, in rare cases, symptoms of myalgia do not subside after statins are discontinued.
When is the best time to take rosuvastatin?
Studies show that some of the newer statins can be just as effective when taken in the morning. HMG-CoA reductase inhibitors such as atorvastatin and rosuvastatin are more potent than older statins. They have half-lives of at least 14 hours. Extended-release fluvastatin, or Lescol XL, can be taken at any time of day.
What does leg pain from statins feel like?
One of the most common complaints of people taking statins is muscle pain. You may feel this pain as a soreness, tiredness or weakness in your muscles. The pain can be a mild discomfort, or it can be severe enough to make your daily activities difficult.
Is it OK to take vitamin D with atorvastatin?
No interactions were found between atorvastatin and Vitamin D3. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Is there an alternative to atorvastatin for myopathy?
Management of Myopathy. Alternatives with a lower potential to induce myopathy have been explored, including the use of fluvastatin extended release, low-dose rosuvastatin, every-other-day dosing of atorvastatin or rosuvastatin, and twice weekly rosuvastatin, though these regimens are not approved by the FDA.
Which is cheaper to take atorvastatin or rosuvastatein?
In USA, Atorvastatin is considerably cheaper than Rosuvastatin and in some managed care systems (HMO in its various variations) even when a patient was on Rosuvastatin, decisions were made for monetary reasons that forced the patients to switch to Atorvastatin, unless they were willing to pay the entire cost for Rosuvastatin on their own.
What is the myopathy rate for fluvastatin 80 mg?
The Prediction of Muscular Risk in Observational Conditions (PRIMO) study reported a myopathy rate of 10.5% of patients (832 out of 7,924) who were receiving high-dose statin therapy (fluvastatin 80 mg; atorvastatin 40 or 80 mg; pravastatin 40 mg; or simvastatin 40 or 80 mg) with a median onset of 1 month.
Which is worse for myalgia atorvastatin or rosuvastatins?
As observed and known, atorvastatin, a second generation lipid lowering agent causes myalgia which is seen in lesser extent and in lesser severity with rosuvastatin therapy.