What would blocking the CD8 receptor do?

Here, we show that autoreactive CD8+ T-cells are highly dependent on CD8 for ligand-induced activation via the T-cell receptor (TCR). As a consequence, “blocking” anti-CD8 antibodies can suppress autoreactive CD8+ T-cell activation in a relatively selective manner.

What do CD8 T cells do?

CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous or virally infected cells, and CD8-positive suppressor T cells, which restrain certain types of immune response.

What is anti-CD8?

Early studies showed that preincubation with anti-CD8 antibodies can block conjugate formation between effector and target cells (16) and inhibit CD8+ T-cell activation in response to cognate pMHCI presented on the target cell surface (17-20).

What is T cell?

T cell, also called T lymphocyte, type of leukocyte (white blood cell) that is an essential part of the immune system. T cells are one of two primary types of lymphocytes—B cells being the second type—that determine the specificity of immune response to antigens (foreign substances) in the body.

What is the role of MHC in T cell activation?

Antigen-presenting cells display three types of protein molecules on their surface that have a role in activating a T cell to become an effector cell: (1) MHC proteins, which present foreign antigen to the T cell receptor, (2) costimulatory proteins, which bind to complementary receptors on the T cell surface, and (3) …

What does high CD8 count mean?

An elevated CD8 cell count is associated with an increased risk of HIV treatment failure for patients who initially achieve an undetectable viral load, investigators from the US military report in the online edition of the Journal of Acquired Immune Deficiency Syndromes.

How do you activate CD8 T cells?

Despite the absence of CD4+ T cells, the tg CD8+ T cells can be activated by LCMV infection class I tetramers (44) or by LCMV gp33 peptide-pulsed DCs, respectively (data not shown).

How do you deplete T cells?

T cell depletion methods can be broadly categorized into either physical or immunological. Examples of physical separation include using counterflow centrifugal elutriation, fractionation on density gradients, or the differential agglutination with lectins followed by rosetting with sheep red blood cells.

How do depletion antibodies work?

These antibodies are classically thought to work through a variety of mechanisms. It includes the inhibition of ligand binding to specific receptors, the blockade of receptor activation, thus interfering with signaling pathways, and/or through their ability to deplete tumor cells.