What kind of drug is Osmitrol?

Mannitol is a diuretic used to force urine production in people with acute (sudden) kidney failure. Mannitol injection is also used to reduce swelling and pressure inside the eye or around the brain. Mannitol is available under the following different brand names: Osmitrol.

What type of drug is mannitol?

Mannitol IV belongs to a class of drugs called Diuretics, Osmotic Agents.

Can you overdose on mannitol?

Signs and symptoms of overdose with mannitol may include acute renal failure, electrolytes imbalance, hypervolaemia, CNS toxicity. Prolonged administration or rapid infusion of large volumes of hyperosmotic solutions may results in circulatory overload and acidosis.

What are the side effects of mannitol?

COMMON side effects

  • dry mouth.
  • excessive thirst.
  • headache.
  • nausea.
  • vomiting.
  • excess urination.

When should you not take mannitol?

You should not receive mannitol if you are allergic to it, or if you have:

  • severe or long-term kidney disease;
  • swelling or congestion in your lungs;
  • severe heart failure;
  • bleeding in your brain that is not related to surgery;
  • severe dehydration; or.
  • if your kidneys have already shut down and you are unable to urinate.

Does mannitol lower BP?

There was a mild decrease in blood pressure and a mild increase in cerebral blood flow following mannitol, but little difference between the first hour following a bolus (when the viscosity and hematocrit were decreased) and hours 2-4 (when they were near baseline).

Why mannitol is given in head injury?

Mannitol is a sugar alcohol solution which is sometimes effective in reducing brain swelling after head injury.

How does mannitol treat drug overdose?

Mannitol may reverse the effects of ciguatoxin by inhibiting ciguatoxin-induced opening of sodium channels and reducing cellular excitability. Mannitol may also increase the dissociation of ciguatoxin from its binding sites on cell membranes.

Why is mannitol bad for you?

There are side effects and risks. It can have the effect of drawing water from the intestinal wall. Taking in too much water can cause diarrhea, abdominal pain, and gas. It has also been associated with heart failure, electrolyte abnormalities, and low blood volume.

Who should not take mannitol?

You should not receive mannitol if you have severe kidney disease, lung swelling or congestion, severe heart failure, severe dehydration, bleeding in your brain not caused by surgery, or if your kidneys have already shut down and you are unable to urinate.

Can mannitol be given in high blood pressure?

At large doses mannitol increases excretion of sodium and potassium. Initially, mannitol acutely raises plasma and extracellular osmolality, which leads to an increase in circulating blood volume. This leads to increase in stroke volume, cardiac output, and blood pressure.

Why mannitol is not used in heart failure?

Mannitol may cause excessive expansion of the intravascular space when administered in high concentrations at a rapid rate. This may result in congestive heart failure and pulmonary edema.