What kind of cancer does benzidine cause?

Which cancers are associated with exposure to benzidine? Occupational exposure to benzidine results in an increased risk of bladder cancer, according to studies of workers in different geographic locations.

Is benzidine specific for blood?

Several presumptive tests have been described for blood stains recognition [1], [2], [3], and one of the most used is Benzidine and its derivative Tetramethylbenzidine (TMB) [4]. Both reagents have similar sensitivity, specificity, and stability [5].

Why is benzidine a carcinogen?

There is sufficient evidence in humans for the carcinogenicity of benzidine. Benzidine causes cancer of the urinary bladder. There is sufficient evidence in experimental animals for the carcinogenicity of benzidine.

Why is benzidine bad?

Available studies indicate that some benzidine-based dyes cause cancer in experimental animals and are converted in animals and humans to benzidine. From the accumulated evidence, OSHA and NIOSH conclude that benzidine-based dyes are potential human carcinogens.

How can benzidine be prevented?

Personnel protection: Avoid breathing dusts and fumes from burning material. Keep upwind. Avoid bodily contact with the material. Do not handle broken packages without protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. …

Is benzidine cancerous?

EPA has classified benzidine as a Group A, known human carcinogen.

How do you test for benzidine?

of glacial acetic acid in a clean test-tube, thus obtaining a 0-5 per cent, solution of benzidine hydrochloride. Then either the examining finger of a rectal glove or a clean orange-stick dipped in a faecal specimen is smeared on white filter-paper, and a little of the benzidine solution is poured over the smear.

What is the benzidine test used for?

The benzidine test is most commonly used for the detection of blood in the feces, and was therefore singled out for investigation.

What is benzidine test used for?

What is benzidine reagent?

Description. Benzidine is a grayish-red, yellowish or white colored, very toxic, crystalline aromatic amine that darkens when exposed to air and light. Benzidine has been widely used for the detection of blood and as a reagent in the manufacture of dyes.

What color indicate positive results for benzidine test?

Positive ( + ): a deep blue colour, appearing within 15 seconds.

How do you prepare a benzidine reagent?

Benzidine–pyridine reagent. Mix 18 ml of redistilled pyridine, 12 ml of water, and 3 ml of cone. HC1. Add 10 ml of the benzidine solution, and shake until a clear solution is obtained.