What is the major safety factor related to pancytopenia?
Risk factors for pancytopenia include: Chemotherapy. Exposure to environmental toxins such as benzene or arsenic. Family history of blood disorders.
What are the common manifestation of patients with pancytopenia?
The commonest clinical manifestations of Pancytopenia are usually Fever (86.7%), fatigue (76%), dizziness (64%), weight loss (45.3%), anorexia (37.3%), night sweats (28%), pallor (100%), bleeding (38.7%), splenomegaly (48%), hepatomegaly (21.3%), and lymphadenopathy is (14.7%).
How do you manage pancytopenia?
For pancytopenia itself, treatments include the following:
- Drugs that suppress the immune system (if the immune system is thought to be attacking the bone marrow)
- Drugs that stimulate bone marrow.
- Bone marrow transplant.
- Blood transfusions.
- Stem cell transplant.
- Watchful monitoring (for mild cases)
What are the lab values for pancytopenia?
Pancytopenia is a medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets….Diagnosis
- anemia: hemoglobin < 13.5 g/dL (male) or 12 g/dL (female).
- leukopenia: total white cell count < 4.0 x 109/L.
- thrombocytopenia: platelet count < 150×109/L.
Is pancytopenia a chronic condition?
The condition is not a disease, but a description of the laboratory findings of low blood cells. In the most extreme cases of pancytopenia, a person can have infections, the signs of severe anemia, including fatigue and difficulty breathing, and bleeding.
What virus causes pancytopenia?
Viral infections, especially HIV, parvovirus B19, EBV, CMV, and hepatotropic viruses (A, B, and C) can also result in pancytopenia. Cytopenias are commonly seen in patients with AIDS.
Can Vitamin B12 deficiency cause pancytopenia?
Deficiency of vitamin B12 is a well known cause of megaloblastic anemia and pancytopenia. Splenomegaly and leukoerythroblastosis are much less well known manifestations of B12 deficiency.
Does pancytopenia go away?
The prognosis of pancytopenia depends largely upon its cause. Thankfully, we now have treatments such as transfusions and stimulating factors to help with the specific blood cell deficiencies while the underlying condition is evaluated and treated.
What medicines can cause pancytopenia?
Medications that can affect bone marrow function include chloramphenicol, chemotherapy drugs, thiazide diuretics, anti-epileptic drugs, colchicine, azathioprine, and non-steroidal anti-inflammatory drugs (NSAIDs). The list here covers just some of the potential disease-related pancytopenia causes.
What medicines cause pancytopenia?
What is a pancytopenia?
(pan-SY-toh-PEE-nee-uh) A condition in which there is a lower-than-normal number of red and white blood cells and platelets in the blood. Pancytopenia occurs when there is a problem with the blood-forming stem cells in the bone marrow.
Is pancytopenia an autoimmune disease?
Autoimmune or inflammatory causes of pancytopenia include aplastic anemia, a relatively rare condition, where immune destruction of stem cells is thought to be the primary cause of pancytopenia.
What are the symptoms and causes of pancytopenia?
Pancytopenia is a descriptive term referring to the combination of low levels of all of the types of blood cells including red blood cells ( anemia ), white blood cells (leukopenia), and platelets ( thrombocytopenia ). Symptoms, which often occur due to the reduced levels of these cells,…
Is it possible to get pancytopenia without treatment?
Pancytopenia is serious and should not be ignored. Without treatment, it can lead to life-threatening symptoms that affect the entire body such as oxygen shortage and immune system problems. How common is pancytopenia? Because of its ties to a wide range of illnesses, pancytopenia is a somewhat common blood cell problem.
How are blood transfusions used to treat pancytopenia?
Blood transfusions may be recommended as a treatment option. A doctor may order a transfusion of red blood cells or platelets if a person’s blood counts are extremely low or they are displaying severe symptoms associated with pancytopenia. Other treatments can include:
How is a bone marrow biopsy used to diagnose pancytopenia?
This test places a drop of your blood on a slide to look at the different types of blood cells it contains. To look for a problem with your bone marrow, your doctor will likely do a bone marrow aspiration and biopsy.