What does peak concentration mean?
Peak Concentration. A pharmacokinetic measure used to determine drug dosing. Cmax is the highest concentration of a drug in the blood, cerebrospinal fluid, or target organ after a dose is given.
What is the peak effect of a drug?
PEAK EFFECT: Another estimate of effect, which represents the maximum effect of any single dose administered during a multiple-dose regimen, is strongly recommended for most drugs for most indications.
What are peak plasma concentrations?
(Science: pharmacology) The highest level of drug that can be obtained in the blood usually following multiple doses.
What is Cmax and AUC?
Abstract. In bioequivalence studies, the maximum concentration (Cmax) is shown to reflect not only the rate but also the extent of absorption. Cmax is highly correlated with the area under the curve (AUC) contrasting blood concentration with time.
What does peak mean?
: to reach a maximum (as of capacity, value, or activity) —often used with out. transitive verb. : to cause to come to a peak, point, or maximum. peak.
What is peak level?
The peak level is the highest concentration of a drug in the patient’s bloodstream. Note: Random drug levels may be ordered and are appropriate for monitoring drug usage if drug is being administered by continuous IV infusion.
What is the minimum effective concentration?
Minimum effective concentration (MEC) is the minimum plasma concentration of a drug needed to achieve sufficient drug concentration at the receptors to produce the desired pharmacologic response, if drug molecules in plasma are in equilibrium with drug molecules in the various tissues (Figure 1.3).
What is plasma level time curve?
The area under the blood (or plasma) concentration–time curve reflects the amount of a xenobiotic that has effectively reached the systemic circulation and as such is influenced both by the degree of bioavailability and by the rate at which a xenobiotic is removed from the body.
What is PK curve?
Abstract. The creation of a pharmacokinetic (PK) curve, which follows the plasma concentration of an administered drug as a function of time, is a critical aspect of the drug development process and includes such information as the drug’s bioavailability, clearance, and elimination half-life.
Does peak mean good?
Peak. Peak is a tricky word that can be either a compliment or an insult; like many words, the meaning changes depending on the context (for example, when Ludacris says “my chick bad,” he means she’s actually good).
When is the peak concentration of an oral drug?
The time of peak concentration after administration of oral drug is an often quoted and used pharmacokinetic parameter. It is not well appreciated, however, that the peak times after a single dose and a dose at steady state during a multiple administration regimen can differ significantly.
How long does it take for plasma concentration to peak?
Peak plasma concentrations after an oral dose is approximately 1 h. It is distributed rapidly to all tissues and exhibits an elimination half-life of 3–12 h. It is eliminated primarily in the form of metabolites, but 5–25% of the dose is excreted unchanged in the urine.
How to predict the concentration of a compound?
For compounds displaying mono-exponential decreases in plasma concentrations over time, the concentration-time profile in man can be predicted using the following equation: where C is the concentration at time t, F is bioavailability, D is the dose, ka is the absorption rate, CL is the clearance, and V is the volume of distribution.
When does caffeine reach its peak plasma concentration?
Peak plasma concentrations occur between 15 and 120 minutes after oral ingestion. This wide variation in time may be due to variation in gastric emptying time and the presence of other dietary constituents, such as fiber (Arnaud, 1987).