Is metronidazole safe in pregnancy 2nd trimester?

Use of metronidazole, a common treatment for bacterial vaginosis and Trichomonas vaginalis, should be avoided during the second trimester of pregnancy in this population.

Can metronidazole cause miscarriage in 2nd trimester?

Can taking metronidazole in pregnancy cause miscarriage? While no increased chance of miscarriage in pregnant women who had taken metronidazole was identified in one study, one further study did identify a possible link between miscarriage and use of metronidazole in early pregnancy.

What will happen if you take metronidazole while pregnant?

Conclusion: During pregnancy, treating bacterial vaginosis and trichomoniasis with metronidazole is effective and offers no teratogen risk. Benefit of metronidazole in the reduction of preterm birth was demonstrated for the combination of this medication with other antibiotics.

Why is metronidazole contraindicated in pregnancy?

Metronidazole is used to treat genitourinary infections and is one of the most commonly used drugs in pregnancy, but it is widely thought to be relatively contraindicated in the first trimester because of a possible increased risk for birth defects.

Does metronidazole cross the placenta?

fertility. Pregnancy: Teratogenic Effects—Pregnancy Category B. Metronidazole crosses the placental barrier and enters the fetal circulation rapidly.

Can metronidazole cause birth defects?

Older studies suggested an increased chance for various birth defects. However, more recent studies could find no evidence that using metronidazole during pregnancy increases the chance for birth defects. The current data do not support an increased chance for birth defects or other harmful effects on the baby.

What pregnancy category is metronidazole?

Pregnancy: Teratogenic Effects—Pregnancy Category B. Metronidazole crosses the placental barrier and enters the fetal circulation rapidly.

What can you not take while pregnant?

What medicines should you avoid during pregnancy?

  • Bismuth subsalicylate (such as Pepto-Bismol).
  • Phenylephrine or pseudoephedrine, which are decongestants.
  • Cough and cold medicines that contain guaifenesin.
  • Pain medicines like aspirin and ibuprofen (such as Advil and Motrin) and naproxen (such as Aleve).

When to use metronidazole in second trimester?

It’s acceptable to use it in the second or third trimester if there is a serious infection like bacterial vaginosis or trichomoniasis. If the infection is not serious, it’s better to wait until after birth or use an alternative antibiotic that’s safe during pregnancy.

Is there a link between metronidazole and miscarriage?

In one small study, there did appear to be a possible link between using Metronidazole during early pregnancy and miscarriage; however, it was unclear whether this increased risk was due to the medication or from the effects of the vaginal infection being treated.

Where does metronidazole go after topical use?

-After oral administration, this drug is secreted in breast milk in concentrations similar to those found in the plasma. -Since some drug may be systemically absorbed following vaginal administration, excretion in human milk following topical use is possible.

How is metronidazole used to treat bacterial vaginosis?

Morales and colleagues3 demonstrated that oral metronidazole therapy reduced the rate of preterm births for pregnant women with bacterial vaginosis and a previous history of preterm birth when compared with women who received placebo (18 percent versus 39 percent).